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Molecular cellular mechanisms of Peptide regulation of melatonin synthesis in pinealocyte culture.
Bull Exp Biol Med. 2012 Jun;153(2):255-8
Authors: Khavinson VKh, Linkova NS, Kvetnoy IM, Kvetnaia TV, Polyakova VO, Korf HW
Abstract
The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture. Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium. Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.
PMID: 22816096 [PubMed - in process]
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