 | Related Articles |
Modifications of glycans: biological significance and therapeutic opportunities.
ACS Chem Biol. 2012 Jan 20;7(1):31-43
Authors: Muthana SM, Campbell CT, Gildersleeve JC
Abstract
Carbohydrates play a central role in a wide range of biological processes. As with nucleic acids and proteins, modifications of specific sites within the glycan chain can modulate a carbohydrate's overall biological function. For example, acylation, methylation, sulfation, epimerization, and phosphorylation can occur at various positions within a carbohydrate to modulate bioactivity. Therefore, there is significant interest in identifying discrete carbohydrate modifications and understanding their biological effects. Additionally, enzymes that catalyze those modifications and proteins that bind modified glycans provide numerous targets for therapeutic intervention. This review will focus on modifications of glycans that occur after the oligomer/polymer has been assembled, generally referred to as post-glycosylational modifications.
PMID: 22195988 [PubMed - indexed for MEDLINE]
compound library screening small molecule library custom peptide synthesis
No comments:
Post a Comment