[A case of multiple liver metastases of gastric cancer successfully treated by combination chemotherapy of s-1 and Paclitaxel].

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[A case of multiple liver metastases of gastric cancer successfully treated by combination chemotherapy of s-1 and Paclitaxel].

Gan To Kagaku Ryoho. 2012 Jul;39(7):1135-8

Authors: Yasuda S, Komatsubara T, Inamoto S, Lee J, Teramura Y, Hashida S, Akamatsu S

Abstract
A 54-year-old man underwent distal gastrectomy for early gastric cancer in September 2002. CT performed 6 months after the operation revealed liver metastases, and they were resected. Hepatic arterial infusion therapy of 5-FU was performed; however, multiple liver metastases appeared in October 2003. We added arterial infusion of CDDP to 5-FU, but liver metastases increased. We then applied a combination chemotherapy of S-1 and paclitaxel from February 2004. Subsequently, stable disease continued, and after 67 courses of S-1 plus paclitaxel, we changed the administration to S-1 alone from August 2009. After that, liver metastases did not increase, so we discontinued chemotherapy on August 2010, followed by observation. Progression of liver metastases has not been to date.

PMID: 22790055 [PubMed - in process]

hts screening Paclitaxel Nov-Onxol high throughput screening