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Chemical genomics in plant biology.
Indian J Biochem Biophys. 2012 Jun;49(3):143-54
Authors: Sadhukhan A, Sahoo L, Panda SK
Abstract
Chemical genomics is a newly emerged and rapidly progressing field in biology, where small chemical molecules bind specifically and reversibly to protein(s) to modulate their function(s), leading to the delineation and subsequent unravelling of biological processes. This approach overcomes problems like lethality and redundancy of classical genetics. Armed with the powerful techniques of combinatorial synthesis, high-throughput screening and target discovery chemical genomics expands its scope to diverse areas in biology. The well-established genetic system of Arabidopsis model allows chemical genomics to enter into the realm of plant biology exploring signaling pathways of growth regulators, endomembrane signaling cascades, plant defense mechanisms and many more events.
PMID: 22803329 [PubMed - indexed for MEDLINE]
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